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The Superior Express
Superior, Nebraska
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October 23, 2014     The Superior Express
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Page 6 The Leader The Week of October 20, 2014 .-., .,,:.,: .. ,,')  ,-i.,  -:  .  Let us get the word out... about y0ur ompany, product or special event with Our affordabie '' PRESS RELEASE SERVICE![  1 Send your message to 179 Nebraska newspapers for one low price! Call (402)476-2851 or visit 55. www.nebpress.com for more details[ 800-447-7436 MORTON BUILDINGS" Built-in 'DNA repair system' busy at work inside all dus By Dr. E. Kirsten Peters My word processor is set up to deal with the errors I make when writing. The programmers who wrote the computer program knew I'd screw things up, so they built in cor- rective func- tions like spellcheck and the abil- ity to simply backspace to delete typos. Those of us old enough to remem- ber manual typewriters still some- times marvel at the ease with which corrections in documents can now be made. Mother Nature also has a built- in corrective function, one at work in organisms as simple as yeast and as complex as people. "Each human cell experiences 10,000 to 100,000 injuries or le- sions in its DNA per day," Profes- sor Michael Smerdon of Washing- ton State University told me. "And there are about 30 trillion cells in an adult human, which makes a lot of errors to correct in each of us." To cope with all that error in the language of life, complex repair processes are at work within us every microsecond. Our cells have repair proteins that can correct er- rors in the genetic code. In other words, DNA is a fragile molecule, prone to problems, but nature copes by having repair capabilities in every cell in your body. Unfortunately, damaged DNA can block the activity of proteins, called RNA polymerases, that "read" the content of genes in DNA for making proteins. "Even small problems in repair can lead to major diseases," Smerdon said. "There are regions in DNA that, if they get damaged and are not repaired quickly, cause more problems than other regions." : Diseases like leukemia, breast cancer, and colon cancer can result from faulty repairs. More rare mala- dies like Cockayne Syndrome and xeroderma pigmentosum are cre- ated by some of the same funda- mental processes. Smerdon is nearing retirement. In recent years he's worked with a young man from China, Peng Man, a post-doctoral researcher in Smerdon's laboratory. In a recent article in the Pro- ceedings of the National Academy of Sciences, Man, Rithy Meas, Kathy Dorgan and Smerdon de- scribed how RNA polymerase can be helped to perform its corrective function. That is an important re- sult in part because someday ill people may be given agents that will increase the effectiveness of repair proteins in the cell. "Repair will never be perfect," Smerdon said. "If it were, there would be no mutations and there- tore no evolutionary change. We wouldn't be here if all repairs were perfectly carried out. But it's got to be pretty close to perfect to avoid disease." For Smerdon, the recent publi- cation in PNAS has been an exten- sion of work he began 40 years ago when he was a post-dec. "I've been fortunate to live through major changes in molecu- lar biology," Smerdon said. "It's been an exciting time in my field." Improvements in laboratory techniques have been one factor leading to the advancement of mo- lecular biosciences. Man, the young post-dec, expects that there will be many new techniques available to researchers when he is Smerdon's age. "By the time I retire, more tech- niques will have led to new theo- ries and a deeper understanding of DNA repair systems," Mao said. "And there will be applications to human medicine." Dr. E. Kirsten Peters, a native of the rural Northwest, was trained as a geologist at Princeton and Harvard. This column is a service of the College of Agricultural, Human, and Natural Resource Sci- ences at Washington State Univer- sity. ". :;2.. 80 +1- Acres Selling, Absolute Auction Gilead, Nebraska Friday, Nov. 14, 2014o Starting Promptly at 1:30 pm Auction to be he/d at the Hebron Secrest Library Basement at 146 N 4th Street, Hebron, NE {?);:;.V.i:,::::7?TZ;: ;'7: "ly-7:: . :::... i a , , i :;;i - :l: ,. --:ii  := " ! :,..; i . i i "-.(7 ....... = ...... "! :! i ' >.f: : i :=. I,,,: .-:"i", ,. 'i- i : " =: ,, ' .4:? " ,-: i: -,,/ ' ,.-  Location: This faim is located at the intersection of Hwy 136 & 53 or 1 Mile East of Gilead, NE. Legal Description: East 1/2 of the Northeast 1/4 except Highway Right of Way all in Section 14-T2N-R1W of the 6th P,M., Thayer Counly, State of Nebraska Farm Description: This farm consists of 80 acres more or less. Them am 72.10 acres of cropland which is level to gently rolling; the balance of 2 acres is grass, waterways & roads. 2013 Farm Service Agency Data: 72 Total Farmland. Wheat base 17.8, Grain Sorghum __. Soybeans 14.3 Total Base Acres 65.8. 2013 Payment $864.00. Base acres subject to change per final FSA review 2013 Taxes: $1.751 64 ............................. : c ........ !,\\;_) i " a:f2".:a'-4.' . ........ : -"':-, - i:@i.=-::: .+:- ,!-; i - -- :- ........... -i GENERAL INFORMATION: Taxes: The 2014 real estate taxes and all pr,or years' taxes snail be the responsibility of the Seller All future years' taxes shal be the responsibility of the Buyer. Posaeesion & Closing: Possession snail be granteO to the Buyer at closing on or before December 12, 2014. Full possession shall be available fat the 2015 crop year. Additiomll Ioformation: A Property Informabon Packet showing FSA intormat=ol aerial photos, lax data, soil types & other pertlnenl information are avadable upon request by contacting the auctioneer Bad Elting at 402-768-7270. Terms: A 20% earnest deposit wll be required from the succ.essfui b=dder the day of the auction, The balance shall be due on or about December 12, 2014. Title insuranos shall be used and the cost shall be shared equally between the Buyer and the Seller. Agency: Brad EI1ing & Company, Inc. is the agent representing the Seller Acreage calculations and data in this brochure have been obtained from sources believed to be reliable although its accuracy cannot be guaranteed by the Seller or the Sellers agents. We ulge prospecth,,e buyers to inspect the tand ad rely on their own conclusions. Announcements made at the aucllon shal lake precedence over advertising. I Auctioneer's Note: This farm will seii absolute tO the h=ghest b=dOer Tee farm Is level to entty rolling and is good production unit and has good narcl surtace access to the farm. John Naiman, Seller Frank Daley, Conservator BvadElting &Company, Inc00 & Ri}E:state Broker, Auctioneer & General Certified Appraiser 145 North 4th St., Hebron, Phone: 402-768-7270 View ":,'ti' auction, on the web: www.eltirauction.om - , y ' . _ %- ,uditorium FREE Clay County Tree Service Tree Trimming/Tree Removal Free Estimates Affordable Pricing Reliable Service Job Site Clean-up Insured Brandon Scheidemann Cell: 402.984.7346 Home: 4o2.773.OlO2 Mark Sullivan wants to represent everyone in the 3rd District. not just political parties or Political Action Committees! [] Mark will work to preserve Social Security and Medicare! [] Mark will fight tor veterans. Mark and his lather are both veterans! [] Mark believes in small business and agriculture as they are the heart- beat of the 3rd District! [] Mark will work for comprehen- sive immigration relorrn I Mark Sullivan will go to Washington D.C. and Get Things Done! MARK SULLIVAN 0000'00^"oress cu" 00'k00,72 Pro-life Democratic candidate for the 3rd Congressiona D strict. Life.long Doniphan. NE resident. Family man; Mark and Kamn, Iwife of 44 years) have 4 grown sons living in the 3rd District. Farmer and cattleman, owns & operates Sullivan &SulliVan :,,